| Safe Engineering Services & technologies Ltd | Quebec |
| Safe Harbour Informatics | British Columbia |
| Safe Lagoon Software | |
| Safe Software | British Columbia |
| Safehouse | |
| SAFI Quality Software, Inc. | Quebec |
| Sage Computers | Saskatchewan |
| Sage Creek Software | |
| Sage Innovation | Quebec |
| Sage Media | Ontario |
| Sage Recruiting | |
| SAGE, Systèmes avancés de gestion d'entreprises, Inc. | Quebec |
| SageData Solutions | Ontario |
| SageData Solutions, Inc. | Ontario |
| Sagenay Média | Quebec |
| SageTea Software | |
| Saguaro Biosciences | |
| Sahar Communications | Alberta |
| Saiga Systems Software, Inc. | Alberta |
| Saigal Media | Ontario |
| Saigontek | Ontario |
| Saint Code | |
| Saint John Airport | |
| Saint Mary's Master of Technology Entrepreneurship & Innovation | Nova Scotia |
| Saint Mary's University | Nova Scotia |
| Saint Mary's University - Department of Mathematics and Computing Science | Nova Scotia |
| Saint Mary's University - M.Sc. in Computing & Data Analytics | Nova Scotia |
| Saint Mary's University Arthur L. Irving Entrepreneurship Centre | |
| Saint Mary's University Sobey School of Business | Nova Scotia |
| Saint-Hyacinthe Technopole | Quebec |
| Saint-Louis Communications | Quebec |
| SAIS Interconnexions, Inc. | |
| SAIT Polytechnic - Electronics Engineering Technology | Alberta |
| SAIT Polytechnic - Software Development | Alberta |
| Sajus Technologies, Inc. | Ontario |
| Sak Data Products Ltd | Ontario |
| Salem Software, Inc. | Ontario |
| Sales Leads Pro | Ontario |
| Sales Outsource Solutions | |
| Sales-track | |
| SalesBinder | British Columbia |
| Salesboom.com | |
| SalesChoice, Inc. | |
| Salesfloor | |
| Salesforce Canada Corporation | Ontario |
| SalesForce Training | Ontario |
| SalesHub | |
| SalesNOW | Ontario |
| SalesWays | Ontario |
| SalesXperts, Inc. | British Columbia |