| Salient Energy | |
| Salient Marketing | Ontario |
| Salkreation | Ontario |
| Sallient Business intelligence, Inc. | |
| salonMonster Software Ltd | British Columbia |
| SalonScale Technology, Inc. | |
| Salt Edge, Inc. | Ontario |
| Salt Spring Design | British Columbia |
| Salt Water Digital | |
| Saltmedia Solutions | Alberta |
| Salumatics, Inc. | Ontario |
| Sam Sandhu Computers | Alberta |
| Sam's Technology Solutions Ltd | |
| Samallbox CMS | British Columbia |
| Samco Software, Inc. | British Columbia |
| Samdesk, Inc. | |
| Samdisha Business Consultants, Inc. | |
| Same Day Geek | British Columbia |
| Sametrica | |
| Samson Design Studios | Manitoba |
| Samsung Ads | |
| Samsung Electronics Canada, Inc. | Ontario |
| Samuelson-Glushko Canadian Internet Policy and Public Interest Clinic | Ontario |
| Samyotech | |
| San@sro, Inc. | Quebec |
| Sanbrex Digital | |
| Sanctuary Cognitive Systems Corporation | |
| Sandbagger Media Ltd | British Columbia |
| Sandbox Media Group | Ontario |
| Sandbox Software Solutions, Inc. | Ontario |
| Sandcastle | |
| Sandelman Software Works | Ontario |
| Sandman Media, Inc. | British Columbia |
| Sandpiper Ventures | Nova Scotia |
| Sandtron Automation Ltd | Ontario |
| Sandtronic Business Systems Ltd | British Columbia |
| Sandvine | Ontario |
| Sandy's Creative Design | Ontario |
| Sangoma | Ontario |
| SaniSoft | |
| SaNOtize Research and Development Corporation | |
| Santuary AI | |
| Sanyou Electrical Appliances | British Columbia |
| Saoyna | |
| SapceRef Business | Ontario |
| Saphir Technologie | Quebec |
| Sapper Labs Group | |
| Sapphire IT Services, Inc. | |
| Sapphire Web Design | Ontario |
| Sapsol Technologies, Inc. | Ontario |