| Universal Knowledge Software | Gauteng |
| Universe Direct | Western Cape |
| Universiteit Stellenbosch - Department of Mathematics | Western Cape |
| Universiteit Stellenbosch - Electrical and Electronic Engineering | Western Cape |
| University of Cape Town | Western Cape |
| University of Cape Town - Computational Biology | Western Cape |
| University of Cape Town - Department of Computer Science | Western Cape |
| University of Cape Town - Department of Electrical Engineering | Western Cape |
| University of Cape Town - Department of Mathematics and Applied Mathematics | Western Cape |
| University of KwaZulu-Natal | |
| University of KwaZulu-Natal - Quantum Research Group | |
| University of KwaZulu-Natal - School of Computer Science | KwaZulu-Natal |
| University of KwaZulu-Natal - School of Mathematical Sciences | KwaZulu-Natal |
| University of Mpumalanga | Mpumalanga |
| University of Pretoria - Department of Computer Science | Gauteng |
| University of Pretoria - Department of Electrical, Electronic and Computer Engineering | Gauteng |
| University of Pretoria - School of Information Technology | Gauteng |
| University of South Africa | |
| University of South Africa - School of Computing | Gauteng |
| University of South Africa - School of Computing Short Learning Programmes | Gauteng |
| University of the Western Cape - Department Of Computer Science | Western Cape |
| University of the Witwatersrand - School of Computer Science and Applied Mathematics | Gauteng |
| University of Venda | Limpopo |
| University of Zululand | KwaZulu-Natal |
| Uniwebserve | Western Cape |
| Upfront Software | Western Cape |
| UPIT | Gauteng |
| Uprise.Africa | Gauteng |
| Urchin Design | Western Cape |
| Urjera Computers CC | Gauteng |
| Uteroo | |
| Uthanda ICT | Gauteng |
| uThetha | Western Cape |
| Utilisoft | Free State |
| Uxie Techlab | KwaZulu-Natal |
| V-Serve Marketing | KwaZulu-Natal |
| V8 Media (Pty) Ltd | Gauteng |
| Vaal University of Technology | Gauteng |
| Valkyri | Western Cape |
| Van Der Spuy Creative (Pty) Ltd | |
| Vanilla Internet Services | Western Cape |
| Vanzyl Media | Gauteng |
| Varistha CC | Western Cape |
| VaultWorks | Western Cape |
| Vector Technologies | Western Cape |
| Vega School | |
| VegaTech | |
| Velocity Group | Gauteng |
| Veneka | Gauteng |
| Venture Electronics (Pty) Ltd | KwaZulu-Natal |