| Zetric | Zaragoza |
| Ziclope Ingenieria Informatica, S.L. | Murcia |
| Ziclotech Distribution Services Ltd | Madrid |
| Ziddea | Ávila |
| Ziknes | Valencia |
| Zikzakmedia | Barcelona |
| Zincapital | A Coruña |
| Zinklar | Barcelona |
| Zinktop | Barcelona |
| ZipSolutions | Barcelona |
| Zityhub, S.L. | Madrid |
| ZLWorks | Barcelona |
| Zokyo | Barcelona |
| Zona Creativa | Málaga |
| Zona Franca de Vigo | |
| Zona Hosting, S.r.l. | Barcelona |
| ZonaVirus | Valencia |
| ZOOM Informática Online | Murcia |
| Zoon Suite, S.L. | Valencia |
| Zubi Labs | Valencia |
| Zuinq Studio, S.L. | Sevilla |
| Zumo Marketing | Madrid |
| Zunder | Palencia |
| Zylon | |
| Zymvol | Barcelona |
| [Q] Interactiva | Asturias |