| Skullbyte | North Rhine-Westphalia |
| Skulteky Elektronik GmbH | North Rhine-Westphalia |
| Sky Blue Microsystems GmbH | Bavaria |
| Skybytes - webdesign und softwareentwicklung | North Rhine-Westphalia |
| skyDSL Deutschland GmbH | Berlin |
| Skyfillers GmbH | Schleswig-Holstein |
| SkyFive AG | |
| SKYLAB aerial vegetation mapping GmbH | |
| SkyNet-IT GmbH | |
| SkySoft GmbH | Bavaria |
| SkySoft Imaging GmbH & Co. KG | Bavaria |
| Skytala GmbH | |
| Skytale GmbH | |
| Slash Berlin | |
| Slash.Digital GmbH | Bavaria |
| Slashdotdash | |
| Sled | |
| SleevesUp! Spaces GmbH | |
| Slice Digital UG | |
| SlidePresenter GmbH | |
| Slider Revolution | |
| SlideVision GmbH | |
| Slius GmbH | Bavaria |
| SLL Automotive Group GmbH | |
| SLM Solutions Group AG | |
| SLY-electronic | Berlin |
| SM Motion Control GmbH | Bavaria |
| SMA Computer GmbH | Bavaria |
| SMAC Softwares GmbH | |
| SMACC GmbH | |
| SMAL GmbH | |
| Small Improvements | |
| Smalt | |
| smart and more GmbH | |
| Smart Battery Solutions GmbH | |
| Smart Calendars | |
| Smart City Factory GmbH | |
| Smart City System Parking Solutions GmbH | |
| Smart Commerce SE | |
| Smart Concierge GmbH | |
| SMART DATA Deutschland GmbH | |
| Smart Dimension | |
| Smart In Media AG | |
| smart IoT GmbH | |
| Smart Mobile Labs AG | |
| Smart Reporting GmbH | |
| Smart Software Solutions GmbH | Bavaria |
| Smart Web Elements | Hesse |
| Smart-IT GmbH | |
| Smart4Diagnostics GmbH | |