| Check Point Software Technologies Ltd | Tel Aviv District |
| Checker Software Systems | Haifa District |
| Chemomab Therapeutics Ltd | |
| CHEQ AI Technologies Ltd | Tel Aviv District |
| Chip PC | |
| Chip PC Technologies | Central District |
| ChipEx2010 | Tel Aviv District |
| ChiPortal | Central District |
| CI Semi | Northern District |
| Cigloo | Central District |
| Cignal.io Ltd | Tel Aviv District |
| Cimatron Ltd | |
| Cinten | |
| Cirrus Minor | Haifa District |
| CISOteria | |
| City Transformer | Tel Aviv District |
| ciValue | Northern District |
| Civnet communication Ltd | Central District |
| Clal Biotechnology Industries Ltd | |
| Claridge Israel | Tel Aviv District |
| Clarity | |
| Classiq | Tel Aviv District |
| ClearML | Tel Aviv District |
| Clearview-Tech | Tel Aviv District |
| Clexio Biosciences Ltd | |
| Click Digital | |
| Clinicode Ltd | Tel Aviv District |
| Cloud of Things | Tel Aviv District |
| Cloud Smart E.R.P. | Tel Aviv District |
| Cloud-Wise | Central District |
| CLOUDance | Central District |
| CloudEdge | Central District |
| CloudEndure | Tel Aviv District |
| Cloudify Platform Ltd | Tel Aviv District |
| Clouding Now | Central District |
| Cloudride | Tel Aviv District |
| CloudTech Solutions | Jerusalem District |
| CloudWize | Central District |
| Clutch Security | |
| CMS Compucenter Ltd | Tel Aviv District |
| Coastal and Marine Engineering Research Institute | |
| Code Red Systems Ltd | Jerusalem District |
| Codename One Ltd | Tel Aviv District |
| Codenroll | |
| CodeOasis Ltd | Tel Aviv District |
| CodeValue Ltd | Tel Aviv District |
| Codim | Tel Aviv District |
| CodiumAI | Tel Aviv District |
| Codota | Tel Aviv District |
| CogniFit | Tel Aviv District |