| Social Service Center B.V. | North Holland |
| SocialReblz | South Holland |
| Socofi Weboplossingen | North Brabant |
| Softbrick B.V. | Gelderland |
| Softec Technologies | |
| Softmedia | |
| Softpak B.V. | South Holland |
| Softrax | South Holland |
| SoftTech | South Holland |
| Software inzicht | Utrecht |
| Softwarebevers | North Holland |
| Softwaregids | North Holland |
| Softwarepakketten.nl | North Holland |
| Softwareplan | Flevoland |
| Softwell | North Holland |
| Sogeti Nederland B.V. | Utrecht |
| Sogyo | Utrecht |
| Soko B.V. | North Holland |
| Solar-systemen.nl | |
| Solcon Internetdiensten B.V. | Flevoland |
| Solid Hosting | Overijssel |
| Solid Partners | Overijssel |
| Solid Ventures | |
| Solidflux | North Holland |
| Soliton Systems Europe N.V. | North Holland |
| Solnet | |
| Solotech | |
| Soluso | Gelderland |
| Solutions Design | South Holland |
| Solutions Factory | |
| Solvec Internet Solutions | South Holland |
| Solventa | Utrecht |
| Solviteers Cloud & Infradiensten | |
| Solynta | Gelderland |
| Sonantic | South Holland |
| Sony Europe B.V. | |
| SOS Solutions | |
| Source | |
| Source.ag | |
| Sourcia | |
| SOWNet Technologies B.V. | |
| Spaaza Technologies B.V. | |
| Space Business Innovation Centre Noordwijk | |
| Space Promotion B.V. | Limburg |
| Spaceti | North Holland |
| Spare IT | North Brabant |
| SPARK | |
| SparkNano | North Brabant |
| Spartner | |
| Speak B.V. | Friesland |