| SoftexCo | Cluj |
| SoftExpert Mobility | Dolj |
| Softimobiliar CRM | Mureș |
| Softimpera | Cluj |
| Softlab | |
| Softland S.R.L. | Cluj |
| Softlead | |
| Softlink Central Europe S.R.L. | |
| Softmagazin S.R.L. | |
| SoftPro | |
| Softventure | |
| SoftwareX S.R.L. | Bucharest |
| Softwin | Bucharest |
| SoftWorks S.R.L. | Bihor |
| SolCreation | Cluj |
| Soleadify | Bucharest |
| Soliton Computers | Bucharest |
| Solutii Web | Bihor |
| SpaceHub Incubator | |
| Spatiul Ro | Iași |
| Spatiuweb | Iași |
| Spearhead Systems | |
| SpeedHost.ro | Timiș |
| Spherik Accelerator | Cluj |
| Sphinx IT | Timiș |
| Spyhce | Cluj |
| SRD Media IT Consulting S.R.L. | |
| SRK S.R.L. | Cluj |
| SRV.RO | Bucharest |
| Star Taxi | Bucharest |
| start-up.ro | |
| Startarium | |
| StarTech Team | |
| Startup Romania | Bucharest |
| Startup Spinner Markeathon | |
| StartupCafe.ro | |
| StartupCafe.ro | |
| Startweb | |
| StasOnline | Timiș |
| Stater | |
| StepFWD | Bucharest |
| Stimasoft | Bucharest |
| StradaIT | Bucharest |
| Strongbytes | Iași |
| StudioWEBER | Brașov |
| StudioWEBER | |
| Subhi.ro | Bucharest |
| Sun Wave Pharma | Bucharest |
| Superbet Interactive (Romania) Ltd | |
| SupraSoft | Bucharest |