| Resolution Creative | |
| Resolution Data Management Ltd | Cambridgeshire |
| Resolution Design Ltd | |
| Resolution GB Ltd | Hampshire |
| Resolution Therapeutics | |
| Resolve | South Yorkshire |
| Resolve Information Technology | |
| Resonance Ltd | |
| Resource Guru | |
| Resource Management Systems | South Yorkshire |
| Response Electronics Ltd | West Midlands |
| Response IT Services Ltd | Surrey |
| Response One Ltd | Somerset |
| ResponseSource Ltd | |
| ResponseTap Ltd | Greater Manchester |
| Responsiv | |
| Responsive Access | |
| Restart | |
| RestaurantDiary.com Ltd | |
| ResultAs | |
| Resulting Ltd | |
| Results Direct | |
| Results Through Digital | Cheshire |
| ResultsWare Ltd | Shropshire |
| Resultware | Northamptonshire |
| Retable | |
| Retail Express | West Yorkshire |
| Retail Response Ltd | West Yorkshire |
| Retail Systems Technology Ltd | Derry and Strabane |
| Retail Technology Innovation | |
| Retain | East Sussex |
| ReThink Design Ltd | Lancashire |
| Rethink Research | |
| ReThought Ltd | |
| reThrive | |
| RETìníZE | |
| Retro Gamer | Dorset |
| Reuben Digital Ltd | |
| Revatics | |
| Revcad Ltd | Staffordshire |
| Revel Innovation Ltd | |
| Reveni | |
| Reviseopen Ltd | Greater Manchester |
| Revive Digital | |
| Revive Eco | |
| Revivocell Ltd | |
| RevLifter | |
| Revo I.T. Ltd | Glasgow |
| RevoluGen Ltd | |
| Revolut Ltd | Greater London |