| Qpick | Vilnius |
| Raibec | Vilnius |
| Recaras, UAB | |
| RedTrack Technologies Ltd | |
| Registras.lt | |
| Repsense | |
| ROCKIT Vilnius | Vilnius |
| Roventa | Vilnius |
| Ruby on Rails lietuviskai | Vilnius |
| S.Y.B. Lithuania | Vilnius |
| S4sure | |
| Saskaita123.lt | |
| SauleNet | |
| Saulėtekio slėnio mokslo ir technologijų parkas | |
| SAVY | Vilnius |
| SBS Group | Vilnius |
| Scallop Group | |
| Scanwatch | |
| Scimore UAB | Vilnius |
| SDK.finance | |
| SeaRadar | |
| searchnode.net | Kaunas |
| SEB Lietuvoje | |
| Seems Neat Development | Vilnius |
| SeemsNeat | |
| Segfoltas | |
| SemanticForce | |
| SEO Akademia | |
| seo.lt | Vilnius |
| Seogenerolai | |
| Seosite | Vilnius |
| Sertek Media | Vilnius |
| serv.lt | Vilnius |
| serveriai.lt | Vilnius |
| serveris.lt | Vilnius |
| ServiceNet | Klaipėda |
| Šiaulių universitetas | Šiauliai |
| Šiaulių valstybinė kolegija | |
| Šiaurės Lietuvos kolegija | Šiauliai |
| Siemens Lietuva | Vilnius |
| Skycop | |
| Skytech UAB | Vilnius |
| Smart Customizer | Vilnius |
| Smartivus | |
| SOFT4 | |
| Softera | |
| SoftiSite | Vilnius |
| Softneta | |
| Solidi Apsauga | Vilnius |
| Solutionlab | Vilnius |