| Develec CC | Western Cape |
| Development IT Solutions CC | Gauteng |
| DevEnterprise Software | KwaZulu-Natal |
| Device SA | Gauteng |
| DevLabs CC | Western Cape |
| Dezign-IT | |
| Dezina Web | Gauteng |
| Dial a Nerd | Gauteng |
| DialSA | Western Cape |
| DiaMatrix | Gauteng |
| Diarize Me | Western Cape |
| Digiata Technologies | Western Cape |
| Digibility | Gauteng |
| Digicape | Western Cape |
| Digify Africa | Gauteng |
| DigiMarCon Africa | |
| DigiMarCon South Africa | |
| Digineering | Gauteng |
| DigiServ | Gauteng |
| Digital Angel | |
| Digital Apex (Pty) Ltd | |
| Digital Consulting | |
| Digital Distributors | Western Cape |
| Digital Dynamix | Eastern Cape |
| Digital Interactive | |
| Digital Marketing Agency | Western Cape |
| Digital Marketing Pretoria | Gauteng |
| Digital Planet | Gauteng |
| Digital Puppy | Gauteng |
| Digital Science | Gauteng |
| Digital Solutions Group | Gauteng |
| Digital Watermelon Design | Gauteng |
| DigitalConnexion | |
| DigitalDomainz.com | Western Cape |
| Digitaliseme | |
| DigitalView | Gauteng |
| DigitalworX | KwaZulu-Natal |
| DigitLab | KwaZulu-Natal |
| Dimsoline | KwaZulu-Natal |
| Direct Distribution Services | Western Cape |
| Disaster Recovery South Africa (Pty) Ltd | Gauteng |
| DiskDrive | |
| DK Designs | Western Cape |
| DNA Online | Eastern Cape |
| DNS Business | Gauteng |
| DNS Enterprises | Gauteng |
| Dolphin South Africa | Gauteng |
| Domain Solutions SA | Gauteng |
| Domains.co.cz | Gauteng |
| Dominion IT | |