| Donald Jackson | Western Cape |
| Donkerhoek Data | Western Cape |
| DorTeg Networks | Gauteng |
| Dot Cube | Western Cape |
| Dotslash | Gauteng |
| Dotunleashed | Gauteng |
| Dovecor Digital | Gauteng |
| DPA-Training | Gauteng |
| DracoTec | Gauteng |
| Dragonfly Aerospace | Western Cape |
| Dragonfly Marketing | Gauteng |
| Dreamstate Interactive | Gauteng |
| Druff Interactive | Gauteng |
| Dsignr Digital | Gauteng |
| Dumel Systems | Western Cape |
| Durban IT Solutions | KwaZulu-Natal |
| Durban University of Technology | KwaZulu-Natal |
| Durban University of Technology - Information Technology | KwaZulu-Natal |
| Dynacomm Networks | Western Cape |
| Dynamic Communications | Western Cape |
| Dynamic IT Solutions | Gauteng |
| Dynamic Visual Technologies (Pty) Ltd | Western Cape |
| Dynamics Africa Services (Pty) Ltd | |
| Dynamite | Gauteng |
| E Solutions Automation (Pty) Ltd | Western Cape |
| E Squared | Gauteng |
| E-Jobin | |
| e-Merge | Gauteng |
| E2E Consulting | KwaZulu-Natal |
| EAGLE Technology | Western Cape |
| Eagle-Networking CC | Gauteng |
| EasiWAN | Gauteng |
| Eastern Cape Information Technology Initiative | Eastern Cape |
| Easy Systems Technologies CC | Gauteng |
| Easy2Access | KwaZulu-Natal |
| Easyweb Internet | Gauteng |
| EasyWebz | KwaZulu-Natal |
| Ebiexperts | Gauteng |
| ECAT Online | Gauteng |
| eCenTrix Software | North West |
| Ecom-Solutions.biz | |
| Ecomm Technologies (Pty) Ltd | KwaZulu-Natal |
| eComplete | Western Cape |
| Econet Group | Gauteng |
| Econsultant | Gauteng |
| Eda Technologies | Gauteng |
| Edenvale Computers | Gauteng |
| EDGE Evolve (Pty) Ltd | Gauteng |
| eDisc | Eastern Cape |
| EDM Shop | Gauteng |