| Propella Dev Team | Eastern Cape |
| PROpulsion | |
| ProSolutions | Gauteng |
| ProSysTech | Gauteng |
| Prowebdesign | |
| PSI Systems | Gauteng |
| PST Training | Western Cape |
| Public Investment Corporation | |
| Pure Web Solutions (Pty) Ltd | |
| PyCon ZA | Gauteng |
| Python System Design | Gauteng |
| Q-Kon | Gauteng |
| QBinc | Western Cape |
| QNET Networking Solutions | |
| Qrent | Gauteng |
| Qualica Technologies | Gauteng |
| Quantec Research | Gauteng |
| Quicksearch Hosting Company | KwaZulu-Natal |
| QuickSolve Advertising and IT Solutions | Free State |
| Quickspace | Gauteng |
| Quintica | Gauteng |
| QWERTY Educational Design | Gauteng |
| R Media | KwaZulu-Natal |
| R-Technologies | Gauteng |
| RA Computer Systems | Eastern Cape |
| Rabtron | Gauteng |
| Rae & Associates | Gauteng |
| RainFin (Pty) Ltd | |
| Ramp Group | Western Cape |
| RapidBid South Africa | Gauteng |
| Rapidsoft | Gauteng |
| Raramuri Design | Western Cape |
| Raw IT | Gauteng |
| Rayoni Web Solutions (Pty) Ltd | |
| RDB Consulting | Gauteng |
| Real Pay Pty Ltd | |
| Realtime | Western Cape |
| Realyst Contract Management Ltd | Gauteng |
| Recor | Gauteng |
| Rectron (Pty) Ltd | |
| Red Dor | |
| Red Dot | KwaZulu-Natal |
| Red Herring Digital | Gauteng |
| Red Internet | Gauteng |
| Red Orchid Projects | Western Cape |
| Red Panda Software | Western Cape |
| RedButton | Western Cape |
| RedHot Design | |
| RedNinja Design Studio | Gauteng |
| redPanda Software | |