| SA-Gateway | Gauteng |
| SA-Nethost.com | Western Cape |
| Sabvest Capital Ltd | |
| Sage Intelligence | KwaZulu-Natal |
| Sage South Africa | Western Cape |
| Saglotech IT Solutions (Pty) Ltd | |
| saHOSTplus.com | KwaZulu-Natal |
| SAI | KwaZulu-Natal |
| SAIGEN | |
| Salestronics CC | Western Cape |
| Sand Design Studio | Gauteng |
| Saratoga | Western Cape |
| Saros Consulting | Western Cape |
| SASA Finance (Pty) Ltd | Western Cape |
| Sasfin | |
| Satellite Communication | Gauteng |
| Satellite Connection | Limpopo |
| Savant | Western Cape |
| Savit52 | |
| Savuti Communications | Gauteng |
| SAWebhost.Com | Gauteng |
| SCA - Carolin Botha | Western Cape |
| Scott Web Designs Studio | KwaZulu-Natal |
| Screenquip | Gauteng |
| ScreenVision SA | Gauteng |
| Seacom | Western Cape |
| SecuPlus | KwaZulu-Natal |
| Secure Time Technology | Gauteng |
| Sedibeng TVET College | |
| Seed Academy | Gauteng |
| Seidor Networks | Gauteng |
| Sekhukhune TVET College | |
| Semantica Digital (Pty) Ltd | Western Cape |
| Sentech | Gauteng |
| SEO Studio | Western Cape |
| SEOStrategicSolutions.com | Gauteng |
| Seven Lemons Design Studio CC | Free State |
| SevenC | Gauteng |
| Shalesh Design Consultants (Pty) Ltd | Western Cape |
| Shapeshift | Western Cape |
| Sherpa | Western Cape |
| ShipShape Software | Gauteng |
| Shopkeeper Solutions CC | Eastern Cape |
| Shopstar | Western Cape |
| SignalRSA | Gauteng |
| Silicon Cape Initiative | Western Cape |
| Silicon Overdrive | Western Cape |
| Silver Linings Technologies | |
| SilverSky | Western Cape |
| Silversoft (Pty) Ltd | Gauteng |