| Ydilo | Madrid |
| Year One Partners | Madrid |
| Yeeply | Valencia |
| Yeeply Mobile, S.L. | |
| YEGO Urban Mobility, S.L. | Barcelona |
| Yeneration360 | Barcelona |
| YepCode | A Coruña |
| YieldPlanet, S.A. | Barcelona |
| Ylos Hispania, S.L. | Tarragona |
| Ymant | Valencia |
| Yoigo | Madrid |
| yoSEO Marketing | Madrid |
| YouMobile | Madrid |
| YouShow Creations, S.L. | Madrid |
| Ysios Capital | Barcelona |
| Yumminn | Barcelona |
| Yunbit, S.L. | Madrid |
| Yuplace & Co. | Barcelona |
| Z1 Digital Studio | |
| Zaask - Plataforma Digital, S.A. | |
| Zabros Informáticos | Valencia |
| Zadia Software | A Coruña |
| Zank | Barcelona |
| ZAPIENS Technologies, S.L. | Asturias |
| Zapp-Studio, S.L.U. | Murcia |
| Zasylogic, S.A. | Madrid |
| Zator Systems, S.L. | Granada |
| ZATSolutions | Barcelona |
| ZeCardio Therapeutics | |
| ZeClinics | Barcelona |
| Zed Worldwide, S.A. | Madrid |
| Zeeker Solutions | |
| Zelenza | Madrid |
| Zeleros | Valencia |
| Zen Interactiva | Madrid |
| Zen Republic | |
| Zenoon 31, S.L. | Madrid |
| Zentense | Barcelona |
| Zerintia Technologies | Madrid |
| Zero 2 Infinity, S.L. | Barcelona |
| Zerouno Games, S.L. | Madrid |
| Zest Agency | Madrid |
| Zesto | Asturias |
| Zetric | Zaragoza |
| Ziclope Ingenieria Informatica, S.L. | Murcia |
| Ziclotech Distribution Services Ltd | Madrid |
| Ziddea | Ávila |
| Ziknes | Valencia |
| Zikzakmedia | Barcelona |
| Zincapital | A Coruña |