| Ponticlaro | |
| Pontificia Universidad Católica de Puerto Rico | Puerto Rico |
| Pontis Research | California |
| Pontoro | California |
| Pony Express Business Solutions | |
| Pony.ai | California |
| Poochon Proteomics Solutions | Maryland |
| Poolit | Florida |
| Poornam | Arizona |
| POP | Washington |
| POP Biotechnologies, Inc. | New York |
| Pop Creative Group, Inc. | |
| Pop Digital Marketing | |
| POP Interactive, Inc. | California |
| Pop the Pixel | |
| Pop.in | |
| PopBookings | Missouri |
| PopCheck Technologies, Inc. | |
| PopCom | Ohio |
| Pope Productions | California |
| POPin | California |
| POPio Mobile Video Cloud, LLC | |
| Poplar Homes | California |
| Poply | California |
| Popmenu, Inc. | Georgia |
| PopNet Media, LLC | Alabama |
| Poppinpay, Inc. | |
| Poppins Payroll, LLC | |
| Pops Royalty Software | |
| Popshoplive | |
| Popskull | Illinois |
| PopSQL, Inc. | California |
| Poptools.org | |
| Popular Pays | |
| Popular Science | New York |
| Population Explorer | Montana |
| Popupsmart, Inc. | Florida |
| POPVOX, Inc. | |
| Porch.com, Inc. | |
| Porcine Associates, LLC | California |
| Porkbun, LLC | Oregon |
| Porosome Therapeutics, Inc. | |
| Port | |
| Port CNC, Inc. | Wisconsin |
| Port Netwokrs, Inc. | Maryland |
| Port Therapeutics | |
| Port Townsend Seriously Laidback User Group | Washington |
| Portabl, Inc. | Pennsylvania |
| Portable Applications for USB drives | |
| Portable One, Inc. | California |