| Rugged Robotics | Texas |
| Rugged Software, LLC | |
| Rulai, Inc. | California |
| Rule29 Creative, Inc. | Illinois |
| Rulesware | Illinois |
| Rulex, Inc. | Massachusetts |
| Rumba Solutions | |
| Rumble Entertainment | California |
| RumbleOn, Inc. | |
| Rumi | |
| Rumi Scientific | New York |
| Runa Capital | California |
| Runable | |
| Runaware USA, Inc. | Florida |
| Runbear, Inc. | |
| RunBuggy | |
| Rundeck | |
| RunDiffusion | Utah |
| Rune | California |
| Rune Labs | California |
| Rune Technologies | |
| Runic Games, Inc. | Washington |
| Runner Agency, LLC | |
| Runner EDQ | Florida |
| Runningfish | |
| RunPod, Inc. | |
| RunReveal, Inc. | |
| RunSafe Security | Virginia |
| Runscope | |
| RunSybill | California |
| Runti Systems | New York |
| RunTime Computing Solutions, LLC | Alabama |
| Runtime Revolution | New York |
| Runtime Software | Nevada |
| Runtime Verification, Inc. | |
| RunTitle Data | |
| Runway AI, Inc. | New York |
| Runway Operations, LLC | California |
| Runwise, Inc. | New York |
| RunX | California |
| RUNY Solutions | New York |
| RUP Technologies, LLC | Wyoming |
| Rural Cloud Initiative | Colorado |
| Rural Wireless Association | District of Columbia |
| Ruri Software Technologies, LLC | Florida |
| RUSH Computers Rentals | California |
| Rush ReCommerce | Nebraska |
| Rush University | Illinois |
| Russel Smith | California |
| Russell Energy Corporation | |