| Institute for Advanced Study School of Mathematics | New Jersey |
| Institute for Commercialization of Florida Technology | Florida |
| Institute for Computational and Experimental Research in Mathematics | Rhode Island |
| Institute for Molecular Manufacturing | |
| Institute for Operations Research and the Management Sciences | Maryland |
| Institute for Systems Biology | |
| Institute for Women in Trades, Technology and Science | California |
| Institute of Environmental Sciences and Technology | |
| Institute of Food Technologists | Illinois |
| Institute of Industrial and Systems Engineers | |
| Institute of Information Technology | Texas |
| Institute of Noetic Sciences | |
| Institute of Product Leadership | |
| Institute of Web Design | |
| Institution for Savings | |
| Institutional Capital Network, Inc. | |
| Institutional Venture Partners | California |
| Instituto de Mercadotecnia y Publicidad, S.C. | |
| InstoComp, Inc. | Colorado |
| Instore | California |
| InStride | |
| Instructure, Inc. | Utah |
| Instrument | |
| Instrumental Software Technologies, Inc. | New York |
| Instrumentation Technology Systems | California |
| Instrumented Sensor Technology, Inc. | Michigan |
| Instudio E, Inc. | Florida |
| InStyle Software | Missouri |
| Instylla, Inc. | Massachusetts |
| Insulated Wire, Inc. | New York |
| Insulectro | California |
| Insulet Corporation | |
| InSummary, Inc. | |
| InsuraGuest, LLC | |
| Insurance Technologies Corporation | Texas |
| Insurance Technologies, LLC | Colorado |
| Insurance Web Designs, Inc. | California |
| Insurance Web Sales | North Carolina |
| Insurances Technologies | |
| InsuranceWebsiteServices.com | Florida |
| InsuraTek, LLC | Oregon |
| InsuredMine | |
| InsureLife | North Carolina |
| Insuresoft | Alabama |
| Insurify, Inc. | |
| Insurity, LLC | Connecticut |
| Insurtech Global | Texas |
| InsurTech NY | |
| Inswitch | Florida |
| inSync Computer Solutions | |