| Iotium | California |
| IOVANCE Biotherapeutics, Inc. | |
| Iovera | Florida |
| ioVista, Inc. | Texas |
| Iowa Central | Iowa |
| Iowa Data Centers | Iowa |
| Iowa Digital | |
| Iowa EdTech Collaborative | Iowa |
| Iowa Software Design | Iowa |
| Iowa Solutions, Inc. | |
| Iowa State University Bioinformatics and Computational Biology Graduate Program | Iowa |
| Iowa State University Department of Computer Science | Iowa |
| Iowa State University Department of Electrical and Computer Engineering | Iowa |
| Iowa State University Department of Mathematics | Iowa |
| Iowa State University Laurence H. Baker Center for Bioinformatics & Biological Statistics | Iowa |
| Iowa State University Research Park | Iowa |
| Iowa Web Hosting | Iowa |
| IowaComputerGurus, Inc. | Iowa |
| IoWeb Publishing, Inc. | Iowa |
| IP Access International, Inc. | California |
| IP ArchiTechs Managed Services, LLC | Colorado |
| IP blue Software Solutions, LLC | Florida |
| IP Cores, Inc. | California |
| IP Data Corporation | Florida |
| IP Fabric, Inc. | |
| IP Infusion | California |
| IP International, Inc. | California |
| IP Pathways | Iowa |
| IP Phone Warehouse | Wisconsin |
| IP Pro Tech | Oregon |
| IP Shark | |
| IP Solutions | Indiana |
| IP2Location.com | Florida |
| iPacket | |
| IPADE Business School | |
| iPage | Massachusetts |
| iPass, Inc. | California |
| iPayables, Inc. | California |
| IPB Tech Solutions, LLC | |
| IPBurger | |
| IPC - Association Connecting Electronics Industries | Illinois |
| IPC Systems, Inc. | Georgia |
| IPC Tech | Virginia |
| IPCOM | Florida |
| IPD Analytics | Florida |
| IPD Capital | Florida |
| IPeople | Texas |
| IPera.AI | New York |
| Iperdesign | Pennsylvania |
| iPersonalyze | Texas |