| Salt Studio London Ltd | |
| Salt Web Design Ltd | |
| SALT.agency | |
| SaltDNA | |
| SaltPay | |
| Salviol Global Analytics Ltd | |
| SAM AI Solutions Ltd | |
| Sam Heaton | Greater Manchester |
| Sam Larsen-Disney | |
| Sam McArthur | |
| SAM Software Ltd | Nottinghamshire |
| Samaipata | Greater London |
| Samba Communications Ltd | |
| Samelco | Merseyside |
| Sammy Southall Webworks | Worcestershire |
| Samos Investments | Greater London |
| Samos Investments Advisory Ltd | |
| Sampled | |
| Samran Technologies | Surrey |
| Samsara Therapeutics | |
| Samson Web Design Ltd | |
| Samui Design & Management Ltd | Oxfordshire |
| San Digital | |
| Sanako UK Ltd | |
| Sanbyte Ltd | West Sussex |
| Sandbar | Greater London |
| Sandbox Group | |
| Sanders Design | Cornwall |
| Sanderson | West Midlands |
| Sandhata Technologies Ltd | |
| Sandlebridge | |
| SandSoft | |
| Sandstone Technology | |
| Sandyx Customer Systems Ltd | Greater Manchester |
| Sanger Institute | |
| Sangster Design | |
| Sania Therapeutics | |
| Sano Genetics | |
| Sans Frontiere Ltd | |
| Santander UK plc | |
| SAO IT | |
| Saphire | |
| Sapio Design | Cheshire |
| Sapphire | Gibraltar |
| Sapphire Arts | |
| Sapphire Capital Partners, LLP | |
| Sapphire Solutions Ltd | Buckinghamshire |
| Sapphire Technologies Ltd | Hampshire |
| Sapphiros UK Ltd | |
| SAQ | Hampshire |