| Saracen Fund Managers | |
| Saracen IT Ltd | Buckinghamshire |
| Sarah Ainslie Marketing | |
| Sarah Bates Design | |
| Sarah Hayes | Kent |
| Sarand | |
| Saratoga Software | |
| Sardina Systems | |
| Sareum Holdings plc | |
| Saros Technology Ltd | Oxfordshire |
| Sarsen Technology Ltd | Wiltshire |
| Sarum Biosciences | |
| Sarum Web Design | Wiltshire |
| SAS Applications | Gloucestershire |
| Sasai Fintech | |
| SASCOM Products Ltd | |
| Sat-link | Kent |
| Satago Financial Solutions Ltd | |
| Satalia | |
| Satavia | |
| Satcom Global Ltd | Tyne and Wear |
| Satcoms Innovation Group | |
| Satellite Applications Catapult | |
| Satellite Mediaport Services Ltd | |
| Satellite TV Shop UK | Hertfordshire |
| Satellite Vu | |
| Satellites & Aerials | |
| SATIS | |
| Satisnet Ltd | |
| Satixfy UK Ltd | |
| SatoshiPay | |
| SATs Companion | |
| SatSense | |
| Satsuma | |
| Saturn Solutions Ltd | Kent |
| Satva Softech Ltd | |
| Satyam Technologies | |
| Saulman Design Ltd | Staffordshire |
| SAVA | |
| Savaasachi | |
| Savage & Gray | |
| Savah | Greater London |
| Savant Ltd | Cumbria |
| Savantech Ltd | West Lothian |
| Save & Invest | |
| Save9 Ltd | North Yorkshire |
| Savoy Systems | |
| Savoy Systems Ltd | Nottinghamshire |
| SavvY | |
| Savvy Digital | |