| Sodatech AG | Schwyz |
| Soft Gestion | Fribourg |
| SOFTplus Entwicklungen GmbH | Zug |
| SoftRain | Bern |
| Software Development Conferences | Vaud |
| Software Engineerg Michel | Basel-Stadt |
| Software Support Reich | Thurgau |
| Softwareentwicklung von Programmierer Markus Winter | Ticino |
| SoftwareONE | Nidwalden |
| Sogema Group GmbH | Zurich |
| SoHHytec S.A. | |
| Solana Foundation | |
| Solar-ICT | |
| Solcept AG | Zurich |
| SolNet | Solothurn |
| Solstis S.A. | Vaud |
| SolusVM | |
| Solutions 4 All | Zurich |
| Solvias AG | |
| Solvias AG | |
| SonarSource S.A. | |
| Sonceboz S.A. | |
| Sonect AG | |
| Soneris Realtime GmbH | Zurich |
| Sophia Genetics S.A. | |
| Soprotec Formations S.A. | Geneva |
| Sorba EDV AG | St. Gallen |
| Soreco AG | Zurich |
| SOSdonnées.ch | Geneva |
| SoundChip S.A. | Vaud |
| Sourcepole AG | Zurich |
| Space for Business | |
| Space Innovation | |
| SPACE Metaverse AG | |
| Spacetek Technology AG | |
| Spar+Leihkasse Gürbetal SLG | |
| Spar+Leihkasse Riggisberg AG | |
| Spar- und Leihkasse Bucheggberg A | |
| Spar- und Leihkasse Frutigen AG | |
| Spar- und Leihkasse Wynigen AG | |
| Sparkasse Schwyz AG | |
| SPB TV AG | |
| Spectroplast AG | Zurich |
| Spectrum Dynamics Medical | |
| Spengler Electronic AG | Basel-Landschaft |
| SperiLogic | Solothurn |
| Spescha Visual Design | Grisons |
| Spexis | |
| Spiden AG | |
| SpiderWeb | Aargau |