| SCS - Supercomputing Systems AG | Zurich |
| Scuola universitaria professionale della Svizzera italiana | |
| SDV Schweizer Direktmarketingverband | St. Gallen |
| SDW Software | Zurich |
| SE-CURE AG | Bern |
| Seantis GmbH | Lucerne |
| Search.ch | Schwyz |
| SEBA Bank AG | Zug |
| Secorio AG | Nidwalden |
| SECUDE International AG | Lucerne |
| Secure Link Services AG | Zurich |
| Securecell AG | |
| SecureSafe | |
| Securiton AG | Bern |
| Securix AG | Solothurn |
| Secutix | Vaud |
| Seedspace | |
| Seedstars S.A. | Geneva |
| Seedstars World | Geneva |
| Seedstars World | |
| Seervision AG | Zurich |
| Sekenta AG | Aargau |
| Selexis S.A. | |
| Sellys | |
| Selma Finance AG | |
| Semantic Hub | |
| Senn Chemicals AG | |
| senseLAN | Fribourg |
| Sensimed S.A. | |
| Sensors.ch | Neuchâtel |
| Sensoryx AG | |
| Sensoryx AG | |
| Seologen | |
| Sercon ICT-Services | Zurich |
| Sertek AG | Aargau |
| Service Projects Profile | Solothurn |
| Services-Entrepreneurs | Vaud |
| SES AG | Lucerne |
| Sesamnet | Fribourg |
| session.vc AG | |
| Seven94.net AG | Bern |
| Sevense Robotics AG | |
| Sevensense Robotics AG | |
| sevenskills GmbH | Zurich |
| Sevitec | Thurgau |
| SFL Regulatory Affairs & Scientific Communication GmbH | |
| SGS Société Générale de Surveillance S.A. | |
| Sharp Electronics (Schweiz) AG | Zurich |
| Sherpany | Zurich |
| Shift Cryptosecurity AG | Zurich |