| Redwolf Security, Inc. | Ontario |
| Redwood e-Learning Systems | Ontario |
| ReefNet, Inc. | Ontario |
| ReelData AI | Nova Scotia |
| reelyActive | |
| Reev Tech, Inc. | Ontario |
| Reeves College | |
| Reezy | |
| Référence Systèmes | Quebec |
| Référence Systèmes, Inc. | Quebec |
| Référencement Multi Contacts | Quebec |
| Référencement PME Montréal | Quebec |
| Référencement Web Montréal | Quebec |
| Référencement.ca | Quebec |
| REfficient, Inc. | Ontario |
| RefillInk.ca | British Columbia |
| RefinePro | Ontario |
| Reflective Media, Inc. | Ontario |
| Reflektor Digital | |
| Reflex Enterprise Solutions Group, Inc. | Alberta |
| Reflex Integrated, Inc. | Ontario |
| Reflex Photonics, Inc. | Quebec |
| ReFleX Wireless, Inc. | British Columbia |
| ReformedTech | |
| Refractions Research | British Columbia |
| Refresh Financial | |
| Refresh, Inc. | Saskatchewan |
| Refreshen Up Web Design | Saskatchewan |
| Refreshen Web Design | |
| reFX Audio Software, Inc. | British Columbia |
| Reg.CA | British Columbia |
| Regatronics, Inc. | Quebec |
| Regency Robotics | |
| RegExr | Alberta |
| Regina PC Users Group | Saskatchewan |
| Regina Technology Community | Saskatchewan |
| Région de Coaticook | |
| Région de Thetford | |
| Regis College | |
| Regisco immobilier, Inc. | |
| Register IT | Ontario |
| Register.ca | Ontario |
| Register.ca, Inc. | Alberta |
| Register4less.com | Quebec |
| Registered Hosting | Alberta |
| Registry Clean Pro | British Columbia |
| Regroupement des cégeps de Montréal | Quebec |
| Regroupement des gens d'affaires de la Capitale Nationale | |
| Regroupement Stratégique en Microsystème du Québec | Quebec |
| REGS Consulting | Ontario |