| Réseaux Spectel | Quebec |
| Resemble AI | |
| Reserve Sense | |
| Reshift Media | Ontario |
| Reshift Security | |
| Resilience Software, Inc. | |
| Resitek, Inc. | Quebec |
| Reso-Tech Laurentides, Inc. | Quebec |
| Resologics, Inc. | Quebec |
| Resolute | Manitoba |
| Resolution Financial Software | British Columbia |
| RESolutionsTECH, Inc. | Ontario |
| Resoluweb | |
| Resolve Health Data | |
| Resolved IT | |
| Resolver, Inc. | Ontario |
| Resonance Alliance, Inc. | Ontario |
| Resonance Media and Design | Ontario |
| Resonant Solutions | Ontario |
| ResortSuite | Ontario |
| Résotek Technologies | Quebec |
| Résotel | Quebec |
| Resource Energy Solutions | Alberta |
| ReSource Group Canada | Ontario |
| Resource Management Solutions Group | Ontario |
| Resource Software International Ltd | Ontario |
| Resourcecode Media, Inc. | |
| ResourceMate | Ontario |
| Resourcepad.ca | |
| Response Biomedical Corporation | |
| Response Generators | Ontario |
| Response I.T. | Ontario |
| ResponseMagic | Ontario |
| Responsive, Inc. | British Columbia |
| Ressac | Quebec |
| Ressources Logiques RSO, Inc. | Quebec |
| ReStart | British Columbia |
| Restart Computers | |
| ReStoringData, Inc. | British Columbia |
| RestSoft Systems | Ontario |
| Results Continuum, Inc. | Ontario |
| Resume.com | British Columbia |
| Resurva | |
| ResVerlogiX | |
| Retail Hero | British Columbia |
| Retail Plus Point Of Sale, Inc. | British Columbia |
| Retail POS System | |
| RetailMagic | Prince Edward Island |
| Retellio | |
| Rethink Solutions, Inc. | Ontario |