| SCIEF, Inc. | |
| Sciemetric Instruments ULC | Ontario |
| Scient Analytics, Inc. | |
| Scientific Metrics | Nova Scotia |
| Scientifika | Quebec |
| Scigiene Corporation | Ontario |
| SciNet | Ontario |
| Scispot | |
| Scoop Robotix | British Columbia |
| ScopeMedia, Inc. | |
| Scopify.ai | Ontario |
| ScopServ International, Inc. | Quebec |
| ScorpioNet 2000 | New Brunswick |
| Scotia Logic | Nova Scotia |
| Scotia Logics | |
| Scotia Software | |
| Scotia Software Development Ltd | Nova Scotia |
| ScotiaComp Technologies | |
| Scott Morgan | Alberta |
| Scott Murphy | |
| Scott Sigurdson | Ontario |
| ScottMedia Web Solutions | Manitoba |
| Scout Talent | |
| Scout Technology Guides | British Columbia |
| ScrapIT Software | Ontario |
| Scratchpad Creative, Inc. | British Columbia |
| Screenlevel Web Solutions | Nova Scotia |
| ScreenScape Networks, Inc. | Prince Edward Island |
| ScribbleData | |
| Scribe Technologies | Quebec |
| Scribenote, Inc. | Ontario |
| Scriptics | Ontario |
| ScriptString Ltd | |
| Scrummasters | Ontario |
| Scryent, Inc. | Ontario |
| Sculpin QA | Prince Edward Island |
| ScyForm | Quebec |
| SD Électronique | Quebec |
| SDP, Inc. | Quebec |
| SDQuébec | Quebec |
| SE Telecommunications Ltd | Ontario |
| Sea Breeze Consulting | Prince Edward Island |
| Sea to Sky Network Solutions | British Columbia |
| Seacly Technologies, Inc. | |
| Seacom Marine Electronics | British Columbia |
| Sead Tokalic | Alberta |
| SeafarerAI | |
| Seagrass Consulting, Inc. | Ontario |
| SeamlessMD | Ontario |
| Search Engine Academy.ca | Quebec |