| Smokehouse Design | Manitoba |
| Smoking Gun Interactive, Inc. | British Columbia |
| Smola Designs | |
| Smooth Commerce | |
| Smooth Weblife | Ontario |
| SMRT Computer Solutions | |
| SMRT Marketing | |
| SMRT1 | |
| SMT ASSY Électroniques, Inc. | |
| SMT Hautes Technologies | Quebec |
| SMT Industrial Supply, Inc. | Ontario |
| SMT-ASSY, Inc. | Quebec |
| SMTC Corporation | Ontario |
| SMTP.com | Ontario |
| Snap 360 | Ontario |
| Snap Printing | |
| Snap Projections | |
| Snap SEO | Alberta |
| Snap Technologies, Inc. | British Columbia |
| SnapB2B | |
| SnapFashun Group, Inc. | Quebec |
| Snappa | Ontario |
| SnapPay, Inc. | |
| Snappy | |
| Snappy Techs Computer Repairs | Ontario |
| SnappyDesign.com | British Columbia |
| SnapTrade | |
| SnazCom | British Columbia |
| Snipcart, Inc. | |
| Snipp Interactive, Inc. | Ontario |
| Snips | British Columbia |
| Snowed In Studios | Ontario |
| Snowed In Studios, Inc. | |
| Snowy Mountain Consulting Ltd | British Columbia |
| Snyder Enterprises | Ontario |
| Soap Media, Inc. | |
| Soapbox Studios | British Columbia |
| Soar Creative | Alberta |
| Sobek | Quebec |
| SOC Robotics, Inc. | British Columbia |
| SoCast Digital | |
| Sociable Media | Nova Scotia |
| Sociable, Inc. | |
| Social Hero Media | |
| Social Life Communications | Alberta |
| Social Media 55 | |
| Social Media Camp | British Columbia |
| Social Media Day Halifax Conference | Nova Scotia |
| Social Nature | |
| Social Robots, Inc. | |