| Sites & Bytes Computers | Prince Edward Island |
| SiteSpinner Pro | Ontario |
| SiteTechnology | |
| SiteVue | |
| Sitewebart | |
| SiteWyze | |
| SiteXtra | Quebec |
| Sitros Consulting, Inc. | |
| Sivco, Inc. | Alberta |
| Six Bees Marketing | British Columbia |
| Six Nations Polytechnic | |
| Six Web Solutions | Quebec |
| Sixo Agency | |
| Sixty Degree Capital | |
| sixty4media | British Columbia |
| SJ Softech, Inc. | Ontario |
| SK Computers | Ontario |
| SK Logic | Ontario |
| SK Sparkle Tech | |
| SK8 Wireless Technologies, Inc. | Ontario |
| Skeddly | Ontario |
| Skeena.net | British Columbia |
| Sketchy Corner Studios, Inc. | |
| SKGOLD Hosting | |
| Skille | |
| Skills 4 Techs Americas, Inc. | Ontario |
| Skiva | Ontario |
| Skkynet Cloud Systems, Inc. | |
| Skorski Web Design, Inc. | Ontario |
| Skunkworks Creative Group | |
| Sky High Technology | |
| Sky Valley Web Design | |
| SkyAcres AgroTechnologies | |
| SkyBase Geomatic Solutions, Inc. | Alberta |
| SkyBox Labs | |
| Skybridge Systems, Inc. | New Brunswick |
| Skygauge Robotics | |
| SKYHiDEV Solutions, Inc. | |
| Skyla Computer Services | New Brunswick |
| Skylab Technologies, Inc. | |
| Skylinc | Ontario |
| Skyline Aviation Software | Manitoba |
| Skyline Design | Alberta |
| Skymark Technologies, Inc. | Ontario |
| SkyNET | Ontario |
| SkyNet Broadband Solutions | Ontario |
| Skynet Media | Prince Edward Island |
| Skynet New Media, Inc. | Ontario |
| Skypoint Capital Corporation | Ontario |
| SkyPrep.com | Ontario |