| Simleader | |
| Simline | |
| Simlog, Inc. | Quebec |
| Simmetria, Inc. | Ontario |
| Simmplymacs | Ontario |
| SIMMS | Ontario |
| Simon de la Salle | British Columbia |
| Simon Frase University - Centre for Experimental and Constructive Mathematics | British Columbia |
| Simon Fraser University | British Columbia |
| Simon Fraser University - Bioinformatics | British Columbia |
| Simon Fraser University - Charles Chang Institute for Entrepreneurship | British Columbia |
| Simon Fraser University - Database and Data Mining Laboratory | British Columbia |
| Simon Fraser University - Department of Mathematics | British Columbia |
| Simon Fraser University - School of Computing Science | British Columbia |
| Simon Fraser University - Silicon Quantum Technology Lab | British Columbia |
| Simon Fraser University 4D LABS | British Columbia |
| Simon Fraser University Beedie School of Business | British Columbia |
| Simon Houle Informatique | |
| Simple Courriel.ca | Quebec |
| Simple Détail | Quebec |
| Simple Experience | British Columbia |
| Simple SEO Marketing Ltd | |
| Simple Simple | |
| Simple Sites Web Design | British Columbia |
| Simple Square Productions | Nova Scotia |
| Simple Technology, Inc. | Ontario |
| simplecall.com | Ontario |
| SimpleClick | Quebec |
| SimpleCréation | Quebec |
| Simplegraphics | British Columbia |
| SimpleHR | Ontario |
| Simpler Technology | Alberta |
| Simplexity Systems, Inc. | Ontario |
| Simpli Financial | |
| Simpli Innovations, Inc. | British Columbia |
| Simplicate Interactive, Inc. | Ontario |
| Simplicity Global Solutions Ltd | |
| SimpliERP | |
| Simplified Telephony Ssolutions | Ontario |
| Simplify Wireless | |
| Simplistics | Ontario |
| Simply | British Columbia |
| Simply Better Marketing | |
| Simply CODE IT Solutions, Inc. | British Columbia |
| Simply Creative for You | British Columbia |
| Simply IT | |
| Simply Modbus | Ontario |
| Simply Software Solutions | |
| Simply Stephen | Ontario |
| Simply4 | Quebec |