| Shoplazza | |
| Shoplogix | Ontario |
| shopRBC.com | Ontario |
| ShopToIt, Inc. | Alberta |
| Shopwest Web | Saskatchewan |
| Shore 2 Shore Automation Ltd | |
| Shore Consulting Group | |
| Shoreline Consulting | |
| Shores Canada | Alberta |
| Shortcreative | British Columbia |
| Shoteck | |
| Shout Media | Ontario |
| ShoutCMS | Alberta |
| Showbie | |
| ShowMakers Productions | British Columbia |
| Shree Systems, Inc. | Ontario |
| Shrinking Planet | Ontario |
| Shulist Group, Inc. | Ontario |
| ShyftLabs | |
| SIA Innovations | Quebec |
| Siatris, Inc. | Quebec |
| SiberLogic, Inc. | Ontario |
| Siborg Systems, Inc. | Ontario |
| Sicyon | Quebec |
| Sid Lee | Quebec |
| Side by Side Optics | Quebec |
| Side Walk Toronto | Ontario |
| SideFX | Ontario |
| Sidekick Interactive | |
| Sideways Design | Ontario |
| Siemens Tech Solutions | |
| Sierra Wireless | British Columbia |
| SiftMed, Inc. | |
| SIGA Informatique 2000, Inc. | Quebec |
| Sight Enhancement Systems | Ontario |
| Sight2k | British Columbia |
| Sightline Innovation, Inc. | Ontario |
| Sightz Productions | Ontario |
| SIGM, Inc. | Quebec |
| Sigma Computers Systems | Ontario |
| Sigma Eight, Inc. | Ontario |
| Sigma Software | Ontario |
| Sigma Systematics | |
| SIGMA-RH | |
| SigmaPoint Technologies, Inc. | Ontario |
| Sigmasys | Quebec |
| SigmaXL | Ontario |
| Sigmund | Quebec |
| SIGNA Computer Systems | Ontario |
| Signal Design | Ontario |