| Sheridan College | Ontario |
| Sheridan College - Computer Programming | Ontario |
| Sheridan College - Faculty of Applied Science & Technology | Ontario |
| Sheriitt Services | |
| Sherlock Forensics Ltd | British Columbia |
| SherMATRIX | |
| SHERPA Firme Conseils, Inc. | |
| Sherpa Games, Inc. | Ontario |
| Sherpa Marketing | Ontario |
| SherpaSoft, Inc. | Quebec |
| Sherweb | Quebec |
| SHI Canada | Ontario |
| Shield Advanced Solutions Ltd | Ontario |
| Shield Identity | |
| Shift Analytics, Inc. | |
| SHIFT Energy | |
| Shift IT Corporation | |
| Shift Support | Alberta |
| Shift Technologies, Inc. | |
| Shift180 | Ontario |
| shift8 web toronto | Ontario |
| ShiftIdeas | Ontario |
| ShiftKey Labs | Nova Scotia |
| ShiftUP Consulting | Alberta |
| Shimadzu Software Development Canada, Inc. | Quebec |
| Shine On SEO | |
| Shine Turbine | |
| ShinnyTimes | Ontario |
| Shinydocs Corporation | |
| Shipfusion, Inc. | |
| Shipmates | |
| Shipstone Corporation | |
| ShipTime, Inc. | |
| Shitfsuite | |
| Shiverware Mobile & IoT Solutions | |
| Shivom Computer and Graphics | Ontario |
| Shivtr | Ontario |
| Shoebox Audiometry | Ontario |
| Shoelace | Ontario |
| Shoelace Learning | |
| Shoestring Media | |
| ShooGa Marketing | Quebec |
| Shop Alberta | Alberta |
| Shop Bonsai, Inc. | Ontario |
| Shopbot | |
| ShopCity.com | Ontario |
| ShopEdge Software, Inc. | Ontario |
| Shopify | Ontario |
| Shopify Developers Platform | Ontario |
| Shopifyninja | |