| Skyrocket | British Columbia |
| SkyShow | Quebec |
| SkySys.ca | Alberta |
| Skytech Communications, Inc. | Quebec |
| Skytech Global Ltd | Ontario |
| SkyTrac Systems Ltd | British Columbia |
| SkyTrust, Inc. | |
| SkyWatch | Ontario |
| SkyWatch Space Applications | |
| Skyway West | British Columbia |
| Slaco Computers | British Columbia |
| Sland Studios | Alberta |
| Slateboard Software, Inc. | Ontario |
| Slavtech Marketing, Inc. | |
| Sleepdeprived Computer Techs | British Columbia |
| Sleeq | |
| Slenke, Inc. | |
| SLG Technologies, Inc. | Ontario |
| SLIC Marketing Solutions | British Columbia |
| slik.media | |
| SLIM Montréal | Quebec |
| Sliq Media Technologies, Inc. | Quebec |
| SLV Expert | Quebec |
| SLV Live | |
| SlyFox | Ontario |
| SM consulting Services, Inc. | |
| SM Informatique | |
| SMA | Ontario |
| Smahile Hub | |
| Small Business Quality Solutions | Ontario |
| Small Towne Solutions | Ontario |
| SmallBiz Web Design | |
| SmallPC.com | Ontario |
| Smart Access | |
| Smart CAPA | |
| Smart Card Marketing Systems | Quebec |
| Smart Communities | |
| Smart Compliance | |
| Smart EMP | |
| Smart Energy Event | |
| Smart Farm | |
| Smart Foxes | Alberta |
| Smart Hotel Software | British Columbia |
| Smart IP, Inc. | Ontario |
| Smart IT | |
| Smart IT Solutions, Inc. | Ontario |
| Smart Network Consulting | Ontario |
| Smart PlanIT | Manitoba |
| Smart Rockstars | |
| Smart Solution | Ontario |