| Saco Design, Inc. | Maine |
| Sacramental Scribe | Arizona |
| Sacramento Amiga Computer Club | California |
| Sacramento Angels | California |
| Sacramento City College | California |
| Sacramento Digital Media | |
| Sacramento Internet Marketing Agency | California |
| Sacramento Java Users Group | California |
| Sacramento Software Works | California |
| Sacred Cow Studios | |
| Sacred Heart University | Connecticut |
| Sacred Rides | |
| SacredCowStudios.com | |
| SADA, Inc. | California |
| Saddleback College | California |
| Saderra | |
| Sadler Studio + Design | |
| Sadree Web Design | Florida |
| Sadup Softech | |
| SAE Circuits | Colorado |
| SAE Power | California |
| Saeloun | Massachusetts |
| Saevah | |
| Safar Partners | |
| Safari Circuits, LLC | Michigan |
| SAFE | |
| Safe Fleet | |
| Safe Harbor Computers | Wisconsin |
| Safe Network Solutions | Tennessee |
| Safe Security | California |
| Safe Systems, Inc. | Georgia |
| Safe-Card ID Services | North Carolina |
| Safe-T.net, LLC | Ohio |
| SafeAndVault.com | Indiana |
| Safebase | |
| SafeBranch, Inc. | California |
| SafeBreach, Inc. | California |
| Safecall, Inc. | North Carolina |
| SafeCharge, LLC | |
| SafeChoice, Inc. | Pennsylvania |
| Safecor Medical | Ohio |
| SafeGraph | California |
| Safeguard Global | |
| Safeguard Home Security | Texas |
| Safehold, Inc. | |
| SafeHouse Web Design and Marketing | |
| SafeLain | |
| Safelink Internet | Idaho |
| SafeLogic, Inc. | California |
| Safely You | |