| Sailes | New York |
| SailPoint Technologies Holdings, Inc. | Texas |
| Sails.js | |
| Sailthru, Inc. | New York |
| Sain Technologies, LLC | |
| Saint Anselm College | New Hampshire |
| Saint Augustine's University | North Carolina |
| Saint Elizabeth University | New Jersey |
| Saint Francis Health System, Inc. | |
| Saint Francis University | Pennsylvania |
| Saint James School of Medicine | |
| Saint Joseph's College Indiana | Indiana |
| Saint Joseph's College of Maine | Maine |
| Saint Joseph's University | Pennsylvania |
| Saint Leo University | Florida |
| Saint Louis University Department of Computer Science | Missouri |
| Saint Louis University Department of Mathematics and Statistics | Missouri |
| Saint Louis Unix Users Group | Missouri |
| Saint Martin's University | Washington |
| Saint Mary's College | Indiana |
| Saint Mary's College Department of Mathematics / Computer Science | Indiana |
| Saint Mary's College of California | California |
| Saint Mary's University of Minnesota | Minnesota |
| Saint Mary-of-the-Woods College | Indiana |
| Saint Michael's College | Vermont |
| Saint Paul College | Minnesota |
| Saint Peter’s University | New Jersey |
| Saint Vincent College | Pennsylvania |
| Saint Vincent College Computing and Information Systems | Pennsylvania |
| Saint Xavier University | Illinois |
| Saison Technology International | |
| Saisystems International | Connecticut |
| Saitech, Inc. | Maryland |
| SAJE Pharma | |
| Sakai LMS | |
| Sakal Ventures Series Fund, LLC | Florida |
| Saketa | |
| Saks and Associates | Pennsylvania |
| Sakura Finetek | |
| Sakura Sky | California |
| Sakuu Corporation | California |
| Salad Technologies | Utah |
| Saladax Biomedical, Inc. | Pennsylvania |
| Salarius Pharmaceuticals, Inc. | |
| Salary.com | |
| Salea, Inc. | |
| Salee AI | Delaware |
| Salem Automation, LLC | |
| Salem College | North Carolina |
| Salem Computer Center | Ohio |