| Scandit | California |
| ScanIDme, Inc. | |
| Scanifly, Inc. | |
| Scanlan International, Inc. | Minnesota |
| Scanner One, Inc. | Colorado |
| ScannerTech, LLC | Arizona |
| Scanning America, Inc. | Kansas |
| Scanning Solutions | Texas |
| Scanogen, Inc. | Maryland |
| ScanOnline | North Carolina |
| ScanQ International, Inc. | Georgia |
| ScanSource | South Carolina |
| ScanTastik | Georgia |
| Scante | Kentucky |
| ScanTexas | Texas |
| Scantibodies Laboratory, Inc. | California |
| Scantron | Minnesota |
| Scarab Genomics, LLC | Wisconsin |
| Scared Rabbit | Indiana |
| Scarlet's Web, LLC | Pennsylvania |
| Scayver Graphix | |
| SCB Consulting, LLC | Maryland |
| SCbio | South Carolina |
| SCC | Georgia |
| SCC Soft Computer | Florida |
| SCD Information Technology | |
| SCDB Software | Florida |
| Scenario | California |
| Scenario Digital Media | |
| Scenyc, Inc. | New York |
| Scepter Marketing | |
| Sceptre, Inc. | California |
| ScerIS, Inc. | Massachusetts |
| Schaefer Advertising Co. | |
| Schat Communications | California |
| SCHED, LLC | |
| SchedMD | |
| ScheduleAnywhere | North Dakota |
| SchedulePop | North Carolina |
| ScheduleSource, Inc. | Colorado |
| Schedulista | Washington |
| Schell Games | Pennsylvania |
| Schellman | Florida |
| Schema Design, LLC | |
| Schemata | |
| Scheme Software Corporation | New York |
| Scherbius, LLC | Illinois |
| Scherstad Systems | Wisconsin |
| Schiller International University | Florida |
| Schivo Medical | |