| Schleifring Medical Systems, LLC | Illinois |
| Schmaltz Productions, LLC | |
| Schmartboard, Inc. | California |
| Schmitt ProfiTools, Inc. | Missouri |
| Schmoll Systems | New Mexico |
| Schneider Computer, Inc. | Ohio |
| Schneider Geospatial, LLC | |
| Schnitz Technology | Pennsylvania |
| Schola | Arizona |
| Schola, Inc. | |
| Scholar Rock | Massachusetts |
| Scholastica | Illinois |
| Scholl Consulting Group, Inc. | Maryland |
| Scholly | California |
| Schoodic Solutions | |
| School for International Training | Vermont |
| School Harbor | |
| School Messenger | California |
| School of PE | Ohio |
| School of Visual Concepts Seattle | Washington |
| School Rush, Inc. | Texas |
| School Webmasters | Arizona |
| School Yourself, Inc. | Massachusetts |
| SchoolAuction.net | Oregon |
| SchoolCare | |
| SchoolCNXT | Massachusetts |
| Schoolcraft College | Michigan |
| SchoolCues | Arizona |
| SchoolData.net | Washington |
| SchoolEdge Mobile, Inc. | Michigan |
| SchoolHouse Electronics, Inc. | Ohio |
| Schoolhouse Technologies, Inc. | Washington |
| SchoolInfoApp | Louisiana |
| SchooLinks, Inc. | Texas |
| SchoolMint | |
| Schoology | New York |
| SchoolSparrow | |
| SchoolsPLP | |
| SchoolStatus | |
| Schoolytics | District of Columbia |
| Schooner Capital, LLC | |
| Schoox, Inc. | Texas |
| Schreiner University | Texas |
| Schrock Innovations | Nebraska |
| Schrödinger, Inc. | New York |
| Schulenberg and Associates, LLC | Alabama |
| Schulz Consulting | Connecticut |
| Schure Consulting, LLC | |
| Schurter, Inc. | California |
| Schuyl, Inc. | Pennsylvania |