| Serious Development | |
| Serious Otters Web Development, Inc. | |
| Serivce Fusion | Texas |
| Serlio Software | Wisconsin |
| Sermonix Pharmaceuticals | |
| Seroba Kernel | |
| SeromYx Systems | Massachusetts |
| Serotiny | California |
| SERP Scan | New York |
| SerpApi, LLC | Texas |
| SerpHaus Digital Media | |
| Serpin Pharma, LLC | |
| Serr.biz, LLC | New Jersey |
| Serra Ventures, LLC | Illinois |
| SerraHost | California |
| Serrano World | United States Virgin Islands |
| Serry Systems, Inc. | Virginia |
| SERT Data Recovery | Florida |
| Serv-U | Texas |
| Serval, Inc. | |
| Servant Keeper | Pennsylvania |
| Servarus Systems | Texas |
| Servatron, Inc. | Washington |
| ServBeyond | Maryland |
| ServData, Inc. | Florida |
| serve-you.net, LLC | Virginia |
| ServedBy the Net, LLC | Washington |
| ServeManager | Colorado |
| Server Concepts, LLC | Texas |
| Server Room | New York |
| Server Sea | Nevada |
| Server StorageIO and UnlimitedIO, LLC | Minnesota |
| Server Technology, Inc. | Nevada |
| Server101 | California |
| ServerBoss | Virginia |
| Servercase | California |
| ServerCentral | Illinois |
| Serverless, Inc. | California |
| ServerLogic | Washington |
| ServerPlus | Utah |
| Serverpod | |
| ServerPronto | Florida |
| Servers Grid | South Carolina |
| ServersDirect | California |
| Serverspace | Florida |
| ServerSupply | New York |
| ServerWatch | California |
| ServFrame | |
| Service Autopilot | Georgia |
| Service Communications, Inc. | Washington |