| Shrapnel Games, Inc. | North Carolina |
| Shrine Development | Michigan |
| SHRM | Virginia |
| shrtcode API | California |
| Shrubbery Networks, Inc. | Oregon |
| Shrug Capital | |
| Shub | Colorado |
| Shubpy | |
| Shuffle, LLC | |
| ShuffleLabs | |
| ShufflePoint, Inc. | Pennsylvania |
| Shuffll, Inc. | New York |
| Shufro Security | Massachusetts |
| Shults Dot Com | California |
| Shure, Inc. | Illinois |
| Shutterstock, Inc. | New York |
| Shuttle Pharmaceuticals | |
| ShuttleCloud Corporation | Delaware |
| Shuttlerock Ltd | New York |
| Shy Editor | |
| Shyam Telecom | New Jersey |
| Shyena Techyarns | Delaware |
| Shyhook Internet | Arizona |
| SI Computer Solutions, Inc. | Nevada |
| SI-BONE, Inc. | California |
| Si-Ware Systems | California |
| SI2 Technologies, Inc. | Massachusetts |
| Sia Foundation | Massachusetts |
| Sianey, LLC | |
| Siargo Ltd | California |
| Siarza | |
| Siber Systems, Inc. | Virginia |
| Sibers | California |
| Sibirtech | |
| Siblings Software | |
| Sibme | Texas |
| Sibros Technologies | California |
| Sibyl AI | |
| SIC Drone | Massachusetts |
| Sic Marketing | |
| Sicaweb | Ohio |
| Sickhead Games, LLC | Texas |
| SicommNet | California |
| Sicunet | Massachusetts |
| Sidago Integrated Solutions | |
| Siddhi InfoSoft | California |
| Side | California |
| Side of Software | Tennessee |
| Side-Eight Software | California |
| Sidebar, Inc. | |