| Southern University of New Orleans | Louisiana |
| Southern University System | Louisiana |
| Southern Utah University Department of Computer Science and Cybersecurity | Utah |
| Southern Utah University Department of Mathematics | Utah |
| Southern Utah Unix Users Group | Utah |
| Southern Virginia University | Virginia |
| Southern Web Design | Florida |
| Southern Wesleyan University | South Carolina |
| Southern West Virginia Community and Technical College | West Virginia |
| SouthernBiotech | Alabama |
| SouthernCode | |
| Southernmost Digital | |
| Southfire | |
| Southgate Computers, Inc. | Michigan |
| Southie Autonomy | Massachusetts |
| Southie Health, Inc. | Massachusetts |
| Southpoint Capital Advisors, L.P. | |
| Southpoint Systems, LLC | |
| Southridge Technology | Connecticut |
| Southtown Web Design | |
| SouthWare | Alabama |
| Southway Systems, Inc. | Texas |
| Southwest Baptist University | Missouri |
| Southwest Cyberport | New Mexico |
| Southwest Engineering Concepts | |
| Southwest Microwave, Inc. | Arizona |
| Southwest Minnesota State University | Minnesota |
| Southwest Office Solutions, Inc. | New Mexico |
| Southwest POS | California |
| Southwest Research Institute | Texas |
| Southwest Tel-Supply, LLC | Texas |
| Southwest Wisconsin Technical College | Wisconsin |
| Southwest Wisconsin Technical College IT-Cybersecurity and Network Administration | Wisconsin |
| Southwestern Adventist University | Texas |
| Southwestern Biomedical Electronics, Inc. | Oklahoma |
| Southwestern Christian College | Texas |
| Southwestern Christian University | Oklahoma |
| Southwestern College Computer Science | Kansas |
| Southwestern College Data Science | Kansas |
| Southwestern College Information Systems Management | Kansas |
| Southwestern Illinois College | Illinois |
| Southwestern Indian Polytechnic Institute | New Mexico |
| Southwestern Michigan College | Michigan |
| Southwestern Oklahoma State University | Oklahoma |
| Southwestern University Computer Science | Texas |
| Southwestern University Math | Texas |
| Southwire Company, LLC | Georgia |
| Southworks | Washington |
| Souvie Biodelivery, LLC | Arizona |
| Sovanza, Inc. | |