| Upfront Ventures | California |
| Upgrade Consulting | |
| Upgrade, Inc. | |
| UpGuard, Inc. | California |
| Uphance, LLC | Texas |
| Upheal, Inc. | New York |
| UpHealth, Inc. | Florida |
| UpHonest Capital | California |
| Upic Solutions | Kentucky |
| UPilot, Inc. | Texas |
| UpKeep Maintenance Mangement | California |
| UpKeep Technologies, Inc. | California |
| Upkey, Inc. | Illinois |
| Uplancer Agency, LLC | |
| Upland Software, Inc. | Texas |
| Uplandme, Inc. | |
| UPlanet | |
| Uplift Agency Ltd | Colorado |
| Uplift Media, LLC | |
| Uplift, Inc. | California |
| Uplify | Delaware |
| Uplight, Inc. | |
| UplineSoft, Inc. | |
| UplinkSpyder, Inc. | |
| Uplinq, Inc. | |
| Uplinx Technologies | California |
| Uplogix, Inc. | Texas |
| Uplynk, Inc. | |
| UPM Pharmaceuticals, Inc. | |
| UPONUS Technologies, LLC | Illinois |
| Upped Events | Pennsylvania |
| Upper Iowa University | Iowa |
| Upper Quad, LLC | |
| UpperCASE Computer Solutions | Oregon |
| UppLabs, LLC | Pennsylvania |
| UpPrize | |
| UppTalk | Arizona |
| UPQODE | |
| UpReach | Pennsylvania |
| UpRecruit | Arizona |
| Upright | |
| Upright Communications | Ohio |
| Uprise Partners | |
| Uprite Services | |
| Uprizer Labs, LLC | |
| Uproer | |
| Upscale AI, Inc. | Delaware |
| Upscale.Pro | |
| Upserve, Inc. | Rhode Island |
| Upsher-Smith Laboratories, LLC | Minnesota |