| UpShift Creative Group, Inc. | Illinois |
| Upshop | Texas |
| Upside Health, Inc. | New Jersey |
| Upside Services, Inc. | |
| UpsideOut, Inc. | New York |
| Upsite Technologies, Inc. | New Mexico |
| UpSiteAI | Wyoming |
| Upskill | Virginia |
| Upskillr, Inc. | |
| UpSmith, Inc. | |
| UpSnap | Texas |
| Upsolver | California |
| UPSTACK | New York |
| UpStack Technologies, Inc. | New York |
| UpStart | California |
| Upstart Labs | |
| Upstart Maine | Maine |
| Upstart Network, Inc. | |
| UpStart VC | Utah |
| Upstart Ventures | New York |
| Upstash, Inc. | |
| Upstate Capital Association of New York | New York |
| Upstate Carolina Linux Users Group | South Carolina |
| Upstate Medical University | New York |
| Upstate University of South Carolina | South Carolina |
| Upstrapp, Inc. | |
| Upstream | New York |
| Upstream Bio | Massachusetts |
| Upstream Bio, Inc. | |
| Upstream Security Ltd | California |
| Upstream Tech | California |
| UpStreamMarketing | Texas |
| Upstreet, Inc. | |
| Upswell | |
| UpSwell Marketing | |
| Upswept Creative | |
| Upswing | |
| upSWOT | North Carolina |
| Uptake Medical Technology, Inc. | California |
| Uptake Technologies, Inc. | Illinois |
| UpTech Computer | Kentucky |
| Uptech, Inc. | California |
| Uptempo | Texas |
| Upthrust, Inc. | |
| Uptick Marketing | |
| Uptima Business Bootcamp | California |
| Uptimal | |
| Uptime Legal Systems | Minnesota |
| Uptime Web Solution | |
| Uptime.com | |