| Yohei | Washington |
| YOHOsys | Virginia |
| Yojna Software | Michigan |
| Yoke Consulting, LLC | Illinois |
| Yokel Local | |
| Yoko Co | |
| Yola, Inc. | California |
| yolBe | Illinois |
| YoLinux.com | California |
| Yollamo | Florida |
| Yomari Information Services, Inc. | |
| Yomu AI | |
| Yoneda Labs, Inc. | |
| Yonohub | Michigan |
| Yonomi | Texas |
| YOOBIC, Inc. | New York |
| Yoodli, Inc. | |
| Yoodlize, Inc. | |
| Yooter | Pennsylvania |
| York and Chapel | |
| York Capital Management | |
| York College / CUNY | New York |
| York College of Pennsylvania | Pennsylvania |
| York County School of Technology | Pennsylvania |
| York Electronics | Kentucky |
| York Solutions, LLC | Illinois |
| York Space Systems | Colorado |
| York Technical College | South Carolina |
| York University | Nebraska |
| Yorktel | New Jersey |
| Yorkville Advisors | |
| YorLabs | Oregon |
| Yorty Designs | Ohio |
| Yosi Health | New York |
| Yosko | California |
| YotaLabs, Inc. | California |
| Yotascale | California |
| YOTTA Energy, Inc. | |
| Yotta Sky | Florida |
| Yottaa | Massachusetts |
| Yottamine Analytics, LLC | Washington |
| You are techkY | |
| You Brand, Inc. | Minnesota |
| You Can Be Found | New Jersey |
| You Got Net, LLC | Texas |
| You Need A Budget, LLC | |
| You Science | |
| You've Been Haacked | Washington |
| You-Betcha Interactive, LLC | California |
| You.com | California |