| YesChat | Colorado |
| Yeshaya Dev, LLC | |
| Yeshiva University | New York |
| Yeshvik Solutions, LLC | |
| YesPlz, Inc. | |
| Yesterday's Business Computers, Inc. | New Jersey |
| Yesware, Inc. | California |
| Yet Another Perl Conference | Pennsylvania |
| Yeti | California |
| Yext, Inc. | New York |
| YFS Magazine | New York |
| YGION Biomedical GmH | |
| YHD SoftWare | Texas |
| Yidio, LLC | |
| Yieldclub | |
| Yieldify | New York |
| YieldStreet, Inc. | New York |
| yieldWerx | Illinois |
| YieldX Advisers, LLC | Florida |
| Yii PHP Framework | District of Columbia |
| Yikes, Inc. | Pennsylvania |
| YipitData | New York |
| Yippa | Washington |
| Yippy, LLC | |
| Yiviva | New York |
| YiZRi, LLC | Vermont |
| YK Communications | Texas |
| YL Ventures GP Ltd | California |
| YL&A | Illinois |
| yl.tech | |
| YLinkTech | Florida |
| YlliB, Inc. | New York |
| YLW | New Jersey |
| YMC America, Inc. | Massachusetts |
| YMEO | California |
| Ymmunobio | New Jersey |
| Yo Only Do Once | |
| Yobe, Inc. | Massachusetts |
| Yobi | California |
| Yocom & McKee | Colorado |
| Yodel.io | |
| Yodle | New York |
| Yodlee, Inc. | California |
| Yoeyo Ltd | New York |
| Yofi | Montana |
| Yofitech, LLC | New York |
| Yogi Consulting, LLC | Florida |
| Yogine Solutions | |
| Yogurt Labs, Inc. | California |
| Yoh Serivces, LLC | New York |