| Hyde Park Capital | Florida |
| Hyde Park Venture Partners | Illinois |
| Hydranet | Wyoming |
| HydroCision, Inc. | Massachusetts |
| Hydrogen Technology Corporation | Florida |
| Hydrogen Ventures, LLC | California |
| Hydrogen, LLC | |
| Hydrolix | |
| Hydromer, Inc. | |
| HydroNet | Massachusetts |
| Hydrosat | |
| Hydrosoft International | California |
| Hydrow | Massachusetts |
| Hydrozen, LLC | |
| Hydtech, LLC | Nevada |
| Hyena Information Technologies | Virginia |
| HYFATech | |
| Hyfe, Inc. | Delaware |
| Hygger, LLC | Delaware |
| Hyko | |
| Hykso | California |
| Hyku Biosciences, Inc. | Massachusetts |
| Hyland Software, Inc. | Ohio |
| Hylenr, Inc. | |
| HyLighter | Florida |
| Hyliion, Inc. | |
| Hylite | Illinois |
| Hyopsys | Pennsylvania |
| HYP3R, Inc. | California |
| Hype Kit, Inc. | |
| HypeAuditor | Indiana |
| Hypelife Brands, LLC | |
| Hypepotamus, Inc. | Georgia |
| Hyper art design | California |
| Hyper Company | |
| Hyper Effects, LLC | |
| Hyper Labs, Inc. | New York |
| Hyper Labs, Inc. | |
| Hyper Media Corporation | Maryland |
| Hyper Spectral | Virginia |
| Hyper-Ad | Texas |
| HyperAccel, Inc. | |
| Hyperactive PC, LLC | Connecticut |
| HyperActive Software | Minnesota |
| HyperActive, Inc. | Massachusetts |
| HyperArts, Inc. | California |
| HyperAspect | District of Columbia |
| HyperBeans | |
| Hyperbolic | |
| hyperCision | Illinois |