| Hypercontext | California |
| Hypercube, Inc. | Florida |
| Hyperdo, Inc. | |
| Hyperfine Software | California |
| Hyperfine, Inc. | Connecticut |
| Hyperfine, Inc. | |
| Hyperfluid Solutions | Pennsylvania |
| HyperFormance, Inc. | Virginia |
| Hypergiant Industries, Inc. | Texas |
| HyperGrowthCEO | Utah |
| Hyperhuman | Nevada |
| hyperI/O, LLC | Colorado |
| Hyperion Works | Arizona |
| Hyperion, Inc. | Illinois |
| Hyperionics Technology, LLC | Pennsylvania |
| HYPERLABS | Oregon |
| Hyperlearning Technologies, Inc. | Virginia |
| Hyperledger Foundation | California |
| Hyperlift | Texas |
| Hyperlight | |
| Hyperlinked Web Services | California |
| Hyperlinks Media, LLC | Texas |
| Hyperlocal Cloud, Inc. | |
| Hyperloop Transportation Technologies | California |
| Hypermart | Massachusetts |
| HyperOffice | Maryland |
| Hyperplane | Massachusetts |
| Hyperproof | |
| Hyperquery | California |
| Hyperride Technologies, Inc. | Florida |
| Hyperscience | |
| Hyperskill | |
| Hyperspace Challenge | |
| Hyperspace Ventures, Inc. | North Carolina |
| HyperSurf Internet | California |
| hyperSven, LLC | California |
| hyperSystems, Inc. | Colorado |
| Hypertable, Inc. | California |
| HyperTask | Massachusetts |
| Hypertech Computers, Inc. | Kansas |
| HyperTEK | Michigan |
| HyperTrack | California |
| HyperTrader Global Ltd | Texas |
| HyperTrends Global, Inc. | |
| HyperTunnel | New Jersey |
| Hyperwallet | California |
| HyperWrite | New York |
| Hypgames, Inc. | Florida |
| Hyphen Solutions, LLC | Texas |
| Hypno Design, Inc. | |