| Irys | Texas |
| IRYStec, Inc. | |
| IS Consulting, LLC | Indiana |
| IS Partners | |
| IS Tech Support | California |
| IS&T Consulting Group | |
| IS/OOP Group | Connecticut |
| Isaacs & Associates, Inc. | Washington |
| Isaacson Works Creative Agency | |
| Isaacson, Miller, Inc. | |
| Isabl | |
| ISACA | Illinois |
| Isadora Agency | |
| iSafe Technologies, Inc. | |
| Isak Computing, LLC | Florida |
| iSatisfy.com | Florida |
| iSavvy Marketing, LLC | Texas |
| ISBS Corporation | Illinois |
| ISBX Corporation | |
| ISC Interconnect Solutions Company | California |
| ISC International Ltd | Wisconsin |
| Iscan360 | |
| Ischemia Care | Ohio |
| Ischemix, Inc. | Massachusetts |
| ISCO International | Illinois |
| iScripts.com | Illinois |
| ISD Education, Inc. | Michigan |
| ISDeveloper, Inc. | Florida |
| ISDK | Texas |
| ISE, Inc. | Ohio |
| iSearchByCity, LLC | |
| iSeatz | Louisiana |
| ISEE | Massachusetts |
| Isee Systems, Inc. | New Hampshire |
| iSeed Digital, LLC | |
| Iseek.ai | Pennsylvania |
| iSelect Internet, Inc. | California |
| Isembard | |
| ISEOU | Florida |
| Iserv | Michigan |
| isEven API | California |
| ISF | Florida |
| ISG Solutions | Maryland |
| ISG Technology, Inc. | Kansas |
| ISG-Telecom Consultants | Florida |
| iShare Medical | Missouri |
| iSharingSoft, Inc. | California |
| iShip, Inc. | Washington |
| Ishpi Information Technologies, Inc. | Virginia |
| ISI Software, LLC | Oregon |