| ISI Telemanagement Solutions, LLC | Illinois |
| iSign Solutions, Inc. | California |
| iSimplifyMe | |
| iSiteBuild.com | Maryland |
| isitonline | |
| IsItWP | |
| ISKPRO, Inc. | |
| Isla Bahia Ventures, LLC | Florida |
| Island | Texas |
| Island Computers | Georgia |
| Island Lake Consulting, LLC | Washington |
| Island Pacific | California |
| Island SEO Consultant | |
| Island Training | North Carolina |
| Island Web Solutions | |
| iSmartRecruit | Maryland |
| ISMG | New Jersey |
| ismnet.com | New York |
| ISMS Applications, LLC | Maryland |
| ISN Software Corporation | |
| ISO Manager | Arizona |
| ISOBAUD, Inc. | |
| Isocentric Networks, Inc. | Oklahoma |
| ISOCNET | Kentucky |
| Isoformix, Inc. | |
| iSoftStone, Inc. | Washington |
| Isolary, LLC | |
| Isolation Bio, Inc. | |
| Isolere Bio, Inc. | North Carolina |
| iSolved HCM | North Carolina |
| iSolved Time | Utah |
| Isomedia, Inc. | Washington |
| Isometric Technologies, Inc. | California |
| Isometrix | Georgia |
| Isometry Capital | |
| iSono Health, Inc. | California |
| ISOOSI, LLC | Florida |
| Isoplexis | Connecticut |
| Isoprime Corporation | Illinois |
| Isos Technology | |
| Isosceles Pharmaceuticals, Inc. | |
| IsoSoft Solutions | Illinois |
| Isotope244 Graphics, LLC | New York |
| ISOTrain | Puerto Rico |
| Isotropic Networks, Inc. | |
| iSource Capital | |
| ISOutsource | Washington |
| Isovalent, Inc. | California |
| Isovera | Massachusetts |
| ISP Tracker | |