| REAL Solution Gruppe | |
| Real-Time Systems GmbH | Baden-Württemberg |
| Reality Twist GmbH | Bavaria |
| Realmforge Studios GmbH | |
| RealObjects GmbH | Saarland |
| Realtech | Baden-Württemberg |
| Realtime Partner UK GmbH | North Rhine-Westphalia |
| REALTIME Software GmbH | Bavaria |
| realworld one GmbH & Co. KG | |
| Realyr GmbR | Berlin |
| Rebate Networks GmbH | Berlin |
| RebeIT GmbH | Berlin |
| REBUSmedia | North Rhine-Westphalia |
| Rebuy Recommerce GmbH | |
| Recarb | |
| Receeve GmbH | |
| Reconcept GmbH | |
| Reconex GmbH | |
| Record Türautomation GmbH | North Rhine-Westphalia |
| RecoScript GmbH | Baden-Württemberg |
| Recover4All | Baden-Württemberg |
| recruitro.com | |
| RecTag | |
| Recurity Labs GmbH | Berlin |
| Recycle IT GmbH | Bavaria |
| Red Dot GmbH & Co. KG | |
| Red Freckles | |
| Red Group GmbH & Co. KG | Hesse |
| Red Pineapple Media GmbH | |
| Red-Database-Security GmbH | Hesse |
| REDAXO CMS | |
| Redcode.de | Hamburg |
| redhotmagma GmbH | |
| Redline Technologies Elektronik GmbH | North Rhine-Westphalia |
| Redlop GbR | Bavaria |
| RedMoon Studios GmbH & Co. KG | Bavaria |
| Redsmith | Lower Saxony |
| Redstone | Berlin |
| Redstone Digital GmbH | |
| ReductSoftware UG | |
| REEL Reinheimer Elektronik GmbH | Hesse |
| Refive GmbH | |
| Refixo GmbH | |
| reflect.media GmbH | North Rhine-Westphalia |
| REFLEX Aerospace GmbH | |
| Refoxy Pharmaceuticals GmbH | |
| refuel.green consulting & technologies GmbH | |
| Regenspurger GmbH | Bavaria |
| Regfish GmbH | Hesse |
| regiocom SE | Saxony-Anhalt |