| Regiogate GmbH | Bavaria |
| Regional Hero GmbH | Berlin |
| Regionalmanagement Nordhessen GmbH | |
| RegITs Regionales IT-Servicecenter GmbH | |
| Regnology Group GmbH | |
| rehage-design | Lower Saxony |
| Rehm Software GmbH | Baden-Württemberg |
| REI3 | |
| Reichmann Software Consulting | Hesse |
| Reif und Möller Diagnostic Network AG | Saarland |
| Reikotronic GmbH | North Rhine-Westphalia |
| REIMEDIA GmbH | North Rhine-Westphalia |
| Reimer Computertechnik | Saarland |
| Reinblau | |
| Reinecker Reha-Technik GmbH | Hesse |
| REINER Kartengeräte GmbH & Co. KG | Baden-Württemberg |
| Reinhard Sielemann Software | North Rhine-Westphalia |
| Reinhard Zeilbeck GmbH | |
| Reinhardt Software GmbH | Hamburg |
| Reinhold Bürosysteme GmbH | |
| reINVENT innovation GmbH | |
| REISSMANN Sensortechnik GmbH | Baden-Württemberg |
| Reister Webdesign Christian Reister GmbH | Berlin |
| Reizwerk GmbH | Hesse |
| Rekkur Solutions | |
| Reknova GmbH | North Rhine-Westphalia |
| Relay GmbH | North Rhine-Westphalia |
| relayts UG (haftungsbeschränkt) | Berlin |
| ReliaTech Receptor Ligand Technologies GmbH | |
| rem-IT GmbH & Co. KG | |
| REMA Lipprandt GmbH & Co. KG | North Rhine-Westphalia |
| Remark GmbH | |
| remasolutions GbR | Saxony |
| Remes GmbH | Bavaria |
| remind.me GmbH | |
| Remira Group GmbH | |
| Remote Sensing Solutions GmbH | |
| RemoteMore | Berlin |
| Remus Datentechnik GmbH | Bavaria |
| RENA Technologies GmbH | |
| Renatoo.de | |
| Rencore GmbH | |
| Rendity GmbH | |
| René Unruh | North Rhine-Westphalia |
| Renego | North Rhine-Westphalia |
| Renishaw GmbH | Baden-Württemberg |
| RENO Pölkner Systeme GmbH | Hamburg |
| Renovatio GmbH & Co. KG | North Rhine-Westphalia |
| Rent-a-Byte AG | North Rhine-Westphalia |
| Rentschler Biopharma SE | |