| Reonic GmbH | |
| Reos GmbH | |
| Repairon GmbH | |
| repaste GmbH | |
| Replex GmbH | North Rhine-Westphalia |
| Replique GmbH | |
| Reportix GmbH | |
| Res Media GmbH & Co. KG | Bavaria |
| RESA Systems GmbH | Saarland |
| RESCH Electronic Innovation GmbH | Saxony-Anhalt |
| Research Institute for Applied Knowledge Processing | |
| ResearchGate GmbH | |
| reseen GmbH | Baden-Württemberg |
| Resin GmbH & Co. KG | Baden-Württemberg |
| Resmio GmbH | |
| Resolution Reichert GmbH | Rhineland-Palatinate |
| Resolve Biosciences GmbH | |
| Resolve Biosciences GmbH | |
| Resourceful Humans GmbH | |
| Resourcify GmbH | |
| Response GmbH | North Rhine-Westphalia |
| Ressourcenmangel GmbH | |
| Restate GmbH | |
| Resuscitec GmbH | |
| Rethink Robotics GmbH | Rhineland-Palatinate |
| Retorio | |
| Retraced GmbH | |
| Reusch Computersysteme | Baden-Württemberg |
| Reuter Webdesign GbR | North Rhine-Westphalia |
| Reuther NetConsulting | Bavaria |
| Revel8 GmbH | |
| Revent | |
| Revolver Software GmbH | North Rhine-Westphalia |
| REVORM Designagentur | Hamburg |
| REWE Systems GmbH | North Rhine-Westphalia |
| Rex-Rotary Vertriebsgesellschaft Essen mbH | North Rhine-Westphalia |
| Rex-Rotary Vertriebsgesellschaft für Kopiersysteme mbH | North Rhine-Westphalia |
| Rexx Systems GmbH | |
| RF-Computer Rheine | North Rhine-Westphalia |
| RF-Design GmbH | |
| RFID Basis | North Rhine-Westphalia |
| RG Software | Bavaria |
| RGS Consulting | Baden-Württemberg |
| RGU GmbH | North Rhine-Westphalia |
| RHC GmbH | Thuringia |
| RHEACELL GmbH & Co. KG | |
| Rhein-Spree Software Engineering GmbH | |
| RheinBrücke IT Consulting GmbH | |
| Rheinformat | North Rhine-Westphalia |
| Rheingau WebDesign | Hesse |